Sign Out
Hypersensitivity to active ingredients linagliptin and/or metformin hydrochloride (with symptoms including asthma/bronchial hyperresponsiveness, urticaria or angioedema) or to any of the excipients.
Any type of acute metabolic acidosis (such as lactic acidosis, diabetic ketoacidosis).
Diabetic pre-coma.
Severe renal failure (CrCl < 30 mL/min or eGFR < 30 ml/min/1.73 m2).
Acute conditions with the potential to alter renal function such as: dehydration, severe infection, shock.
Disease which may cause tissue hypoxia (especially acute disease, or worsening of chronic disease) such as: decompensated heart failure, respiratory failure, recent myocardial infarction, shock.
Hepatic impairment.
Acute alcohol intoxication.
Alcoholism.
